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DNA methyltransferase 1

DNA methyltransferase 1

DNA methyltransferase 1 (DNMT1) is the primary enzyme responsible for preserving DNA methylation patterns after DNA replication. By preferentially recognizing hemi-methylated CpG sites, DNMT1 faithfully restores methylation on newly synthesized DNA strands, ensuring stable inheritance of epigenetic information. This activity is essential for embryonic development, genomic imprinting, X-chromosome inactivation, and long-term genome integrity.

Maintenance of DNA Methylation

During S phase, DNMT1 transfers methyl groups from S-adenosylmethionine (SAM) to unmethylated cytosines opposite methylated parental strands. Although mainly a maintenance methyltransferase, it can also mediate context-dependent de novo methylation at selected genomic loci, including transposable elements and imprint control regions.

Regulation and Biological Functions

  • Protein interactions: DNMT1 cooperates with UHRF1 and PCNA to ensure accurate methylation inheritance during DNA replication.
  • Epigenetic regulation: Its activity is controlled by post-translational modifications, including phosphorylation, acetylation, ubiquitination, and O-GlcNAcylation.
  • Biological significance: DNMT1 regulates stem cell maintenance, neuronal development, genome stability, and transposable element silencing. Aberrant expression contributes to cancer, aging, and developmental disorders, making DNMT1 an important therapeutic target for epigenetic drugs such as azacitidine and decitabine.

Frequently Asked Questions (FAQ)

How can I quickly find a dnmt1 product?

To find a dnmt1 product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Oncomedics stock several product codes in the dnmt1 category?

Yes, Oncomedics distributes several product references in the dnmt1 category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for dnmt1 products?

Yes, you can request a quote for dnmt1 products from the product page or by contacting Oncomedics (info@oncomedics.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a dnmt1 product is available to order?

The availability of a dnmt1 product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Oncomedics with the product code or name of the product you are looking for.

What should I do if I cannot find the dnmt1 product I am looking for?

If the dnmt1 product you are looking for does not appear in the catalogue, please contact Oncomedics with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all dnmt1 products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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