Predictive test for personalised anti-tumor treatment
 

Fragmented Antibodies

Secondary antibodies are antibodies that bind to primary antibodies or antibody fragments. 

Fragmented secondary antibodies are antibodies that have been enzymatically digested to remove the Fc region of the antibody, leaving only the antigen-binding Fab or F(ab')2 fragments. 

These fragments are monovalent or divalent, respectively, and can be used to block endogenous immunoglobulins on cells, tissues, or other surfaces, and to block the exposed immunoglobulins in multiple labeling experiments using primary antibodies from the same species. They can also be used to label primary antibodies prior to incubation with the experimental sample. The advantages of using fragment secondary antibodies include eliminating non-specific binding between Fc portions of antibodies and Fc receptors on cells, facilitating better antigen penetration into tissue, and reducing background from primary antibody binding in double staining experiments.

The advantages of using Fab fragment secondary antibodies include:

  • Eliminating non-specific binding between Fc portions of antibodies and Fc receptors on cells, which is particularly important when working with live cells.
  • Facilitating better antigen penetration into tissue, which is important for immunohistochemistry (IHC) experiments.
  • Reducing background from primary antibody binding in double staining experiments.
  • Allowing for direct conjugation to detectable labels through their sulfhydryl groups, ensuring that the active binding site of the antibody is not affected.

 


Frequently Asked Questions (FAQ)

Where can I find fragmented antibodies products on the Oncomedics website?

fragmented antibodies products are available in this section and can be sorted by product families or sub-categories, such as F(ab')2. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the fragmented antibodies category?

The fragmented antibodies category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The F(ab')2 sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a fragmented antibodies product?

To find a fragmented antibodies product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Oncomedics stock several product codes in the fragmented antibodies category?

Yes, Oncomedics distributes several product references in the fragmented antibodies category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for fragmented antibodies products?

Yes, you can request a quote for fragmented antibodies products from the product page or by contacting Oncomedics (info@oncomedics.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a fragmented antibodies product is available to order?

The availability of a fragmented antibodies product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Oncomedics with the product code or name of the product you are looking for.

What should I do if I cannot find the fragmented antibodies product I am looking for?

If the fragmented antibodies product you are looking for does not appear in the catalogue, please contact Oncomedics with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all fragmented antibodies products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.